Resources

Welcome to our searchable resource and literature collection on safer supply and related topics.

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Severe opioid withdrawal, risk of patient-initiated discharge, and some inpatients’ use of unregulated substances prompt clinical and ethical questions considered in this commentary on a case.&nbsp

Case study | 2025
About PWUD, About prescribers, Advocacy, Barriers and enablers, Clinical guidance, Harm reduction, Hesitancy of prescribers , Hospitals, Illegal drugs, Injecting drugs, Safer supply, Stigma, Substitution/OAT, Withdrawal
Guidelines | 2024
About prescribers, Chronic pain, Clinical guidance, Mental health, Opioids, Overdose

This article describes the implementation and evaluation of four Safer Opioid Supply programs (SSPs) in Ontario, one in London and three in Toronto.

Original research | 2024
Barriers and enablers, Diversion, Clinical guidance, Harm reduction, Illegal drugs, Safer supply, Substitution/OAT, Wrap-around services, Overdose
Commentary | 2024
About PWUD, Clinical guidance, Illegal drugs, Mental health, Overdose, Opioids, Xylazine
Toolkit | 2024
About prescribers, Alcohol, Clinical guidance, Hospitals, Transitions in care/treatment, Withdrawal, Wrap-around services
Toolkit | 2024
About PWUD, Clinical guidance, Opioids, Substitution/OAT, Treatment/recovery

This report summarizes the literature on ketamine as a treatment for adults with substance use disorders.

Report | 2024
About PWUD, Clinical guidance, Evidence base, Hallucinogens/psychedelics, Treatment/recovery

This paper discusses how fentanyl and the toxic drug supply complicates hospital Opioid Use Disorder (OUD) care. 

Lit review | 2024
About prescribers, Clinical guidance, Harm reduction, Hospitals, Illegal drugs, Opioids, Overdose, Stimulants, Substitution/OAT, Transitions in care/treatment, Withdrawal, Wrap-around services
Guidelines | 2021
About prescribers, Alcohol, Benzodiazepines, Cannabis, Chronic pain, Clinical guidance, Harm reduction, Mental health, Opioids, Substitution/OAT, Transitions in care/treatment, Withdrawal

To ensure optimal management of opioid use disorder (OUD), the updated 2024 CRISM National Guideline incorporates recent research, clinical insights, and input from individuals with lived experienc

Guidelines | 2024
Barriers and enablers, Clinical guidance, Harm reduction, Overdose, Peer/PWLLE program involvement, Stigma, Substitution/OAT, Treatment/recovery, Withdrawal, Wrap-around services

This paper describes a novel, volunteer physician-led interprofessional approach to identifying patients with opioid use disorder (OUD), initiating buprenorphine, and linking to office-based opioid

Report | 2024
Clinical guidance, Hospitals, Transitions in care/treatment, Substitution/OAT

Is coprescription of hydromorphone tablets or sustained-release oral morphine (opioid risk mitigation guidance [RMG]) and opioid agonist treatment (OAT) associated with subsequent OAT receipt?

Original research | 2024
About PWUD, Clinical guidance, Evidence base, Safer supply, Substitution/OAT, Transitions in care/treatment

We provide a synopsis of the 2024 update of the 2018 National Guideline for the Clinical Management of Opioid Use Disorder, from the Canadian Research Initiative in Substance Matters (CRISM).

Guidelines | 2024
Clinical guidance, Harm reduction, Illegal drugs, Stigma, Substitution/OAT, Treatment/recovery, Withdrawal
Slide deck | 2022
About prescribers, Barriers and enablers, Clinical guidance, Harm reduction, Hospitals, Ketamine, Opioids, Substitution/OAT, Withdrawal

To assess the risk of treatment discontinuation and mortality among individuals receiving buprenorphine/naloxone vs methadone for the treatment of opioid use disorder.

Original research | 2024
About PWUD, Clinical guidance, Mortality, Opioids, Outcomes, Substitution/OAT, Treatment/recovery

The scope of the Publicly Available Specification (PAS) focuses on health-care providers who are able to prescribe medications in Canada with specific emphasis on prescribers who do not consider th

Guidelines | 2024
About prescribers, Alcohol, Barriers and enablers, Clinical guidance, Hospitals, Peer/PWLLE program involvement, Stigma, Substitution/OAT, Withdrawal
Recommendations | 2023
Carries/take-home doses, Clinical guidance, Hospitals, Substitution/OAT, Withdrawal
Guidelines | 2024
Clinical guidance, Hospitals, Substitution/OAT, Transitions in care/treatment

Sublingual buprenorphine is most commonly available in co-formulation with naloxone.

Case study | 2024
About PWUD, Clinical guidance, Hesitancy of prescribers , Substitution/OAT, Withdrawal

Disturbances in emotion regulation among people who use opioids receiving methadone maintenance treatment (MMT) was reported in a few small studies.

Original research | 2024
About PWUD, Benzodiazepines, Clinical guidance, Evidence base, Illegal drugs, Mental health, Opioids, Stimulants, Substitution/OAT

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