Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder

Original research
by
Nosyk, B. et al

Release Date

2024

Geography

Canada

Language of Resource

English

Full Text Available

No

Open Access / OK to Reproduce

No

Peer Reviewed

Yes

Objective

To assess the risk of treatment discontinuation and mortality among individuals receiving buprenorphine/naloxone vs methadone for the treatment of opioid use disorder.

Findings/Key points

Individuals receiving methadone had a lower risk of treatment discontinuation compared with those who received buprenorphine/naloxone. The risk of mortality while receiving treatment was similar between medications.

Design/methods

Population-based retrospective cohort study using linked health administrative databases in British Columbia, Canada. The study included treatment recipients between January 1, 2010, and March 17, 2020, who were 18 years or older and not incarcerated, pregnant, or receiving palliative cancer care at initiation.

Keywords

About PWUD
Clinical guidance
Mortality
Opioids
Outcomes
Substitution/OAT
Treatment/recovery