Resources

Welcome to our searchable resource and literature collection on safer supply and related topics.

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Adapting a Low-threshold Buprenorphine Program for Vulnerable Populations During the COVID-19 Pandemic

This paper examines patient characteristics and initial outcomes of patients served during a rapid protocol shift to telehealth that allowed buprenorphine initiation without an in-person encounter fol
Original research | 2021
Policy/Regulatory, About prescribers, Outcomes, Substitution/OAT, Digital health

Adverse Events During Treatment Induction With Injectable Diacetylmorphine and Hydromorphone for Opioid Use Disorder

Describes a 3-day induction protocol for injectable hydromorphone (HDM) and diacetylmorphine (DAM) used in 3 Canadian studies and examine rates of opioid-related overdose and somnolence during this in
Original research | 2019
Clinical guidance, Evidence base, Harm reduction, Safer supply, About prescribers, Outcomes, Substitution/OAT, Injecting drugs

Characterization of deceased drug users in Denmark based on treatment status: A nationwide retrospective autopsy study

Looked at characteristics of deceased drug users in treatment and not in treatment
Original research | 2021
Overdose, Mortality, Illegal drugs, Substitution/OAT

Community-based Naloxone Coverage Equity for the Prevention of Opioid Overdose Fatalities in Racial/Ethnic Minority Communities in Massachusetts and Rhode Island

Our objective was to determine if US municipalities with high percentages of non-white residents have equitable access to the overdose antidote naloxone distributed by community-based organizations.
Original research | 2021
Overdose, Harm reduction, Equity

Convenience and comfort: reasons reported for using drugs alone among clients of harm reduction sites in British Columbia, Canada

This study aimed to assess prevalence and reasons for using drugs alone among people accessing harm reduction services in BC.
Original research | 2020
Overdose, Harm reduction, Policy/Regulatory, Safer supply, About PWUD, Sex/Gender , Stigma

Diacetylmorphine versus Methadone for the Treatment of Opioid Addiction

We compared injectable diacetylmorphine with oral methadone maintenance therapy in patients with opioid dependence that was refractory to treatment
Original research | 2009
Evidence base, Policy/Regulatory, Safer supply, About prescribers, Outcomes, Illegal drugs, Substitution/OAT

Examining prevalence and correlates of smoking opioids in British Columbia: opioids are more often smoked than injected

The study objectives are to identify the prevalence and correlates associated with smoking opioids.
Original research | 2021
Overdose, Policy/Regulatory, Decriminalization/legalization, Illegal drugs, Small/medium cities, Sex/Gender

Hydromorphone Compared With Diacetylmorphine for Long-term Opioid Dependence: A Randomized Clinical Trial (SALOME)

To test if injectable hydromorphone hydrochloride is noninferior to injectable diacetylmorphine in reducing illicit heroin use for chronic injection opioid users after 6 months of intervention.
Original research | 2016
Evidence base, Policy/Regulatory, Safer supply, Advocacy, About prescribers, Outcomes, Illegal drugs, Substitution/OAT

Impact of overdose prevention sites during a public health emergency in Victoria, Canada

The primary objective of this study was to examine the impacts associated with implementation of overdose preventions sites (OPSs) in Victoria, Canada during a declared provincial public health ove

Original research | 2020
Overdose, Harm reduction, Policy/Regulatory, Outcomes, Illegal drugs, Transitions in care/treatment, Stigma

Implementation of buprenorphine initiation and warm handoff protocols in emergency departments: A qualitative study of Pennsylvania hospitals

We examined hospital staff's perspectives on the processes, challenges, and facilitators to buprenorphine initiation and warm handoff protocols in the ED
Original research | 2021
Overdose, Wrap-around services, About prescribers, Substitution/OAT, Transitions in care/treatment, Stigma, Hospitals

Matériel d’injection : réduire les risques chez les injecteurs de médicaments opioïdes

Recommend best injection practices to reduce infections, while keeping risk in mind
Report | 2015
Harm reduction, Policy/Regulatory, Safer supply, Injecting drugs, SCS/OPS

Men’s and women’s response to treatment and perceptions of outcomes in a randomized controlled trial of injectable opioid assisted treatment for severe opioid use disorder

To test whether there are gender differences in treatment outcomes among patients receiving injectable opioids for the treatment of long-term opioid-dependence.
Original research | 2017
Evidence base, Safer supply, Outcomes, Crime, Illegal drugs, Sex/Gender

Non-medical prescription opioid use and in-hospital illicit drug use among people who use drugs

Illicit drug use while admitted to hospital is common amongst people who use drugs. Furthermore, non-medical prescription opioid use (NMPOU) is increasingly being used by this population.
Original research | 2021
Evidence base, Harm reduction, Safer supply, About prescribers, Illegal drugs, Hospitals

One size does not fit all-evolution of opioid agonist treatments in a naturalistic setting over 23 years

This study aims to model the distribution of different OAT medications within a naturalistic and relatively unrestricted treatment setting (Zurich, Switzerland) over time, and to identify patient char
Original research | 2018
Evidence base, Safer supply, Advocacy, About prescribers, Substitution/OAT, Social benefits

Possible benefits of providing safe supply of substances to people who use drugs during public health emergencies such as the COVID-19 pandemic

To describe the possible benefits of offering safe supply to people who use drugs during public health emergencies like COVID-19
Commentary | 2020
Safer supply, Stimulants

Recovery capital among people receiving treatment for opioid use disorder with buprenorphine

Recovery capital is a strengths-based concept representing the sum of an individual’s resources that support recovery.
Original research | 2021
Equity, Substitution/OAT, Sex/Gender

Safe supply: What is it and what is happening in Canada?

Webpage | 2021
Overdose, Policy/Regulatory, Safer supply, Advocacy, Outcomes, Illegal drugs, Injecting drugs

Take home injectable opioids for opioid use disorder during and after the COVID-19 Pandemic is in urgent need: a case study

In this case it is presented and discussed that if a carry was possible during the pandemic, then the carry could continue post COVID-19 to address a gap in our approach to individualize care for p

Case study | 2021
Harm reduction, Policy/Regulatory, Safer supply, Outcomes, Injecting drugs, Diversion, Carries/take-home doses

The Andalusian trial on heroin-assisted treatment: a 2 year follow-up

In 2003, a randomised controlled trial comparing injected diacetylmorphine and oral methadone was carried out in Andalusia, Spain.
Original research | 2010
Evidence base, Harm reduction, Policy/Regulatory, Safer supply, About prescribers, Outcomes, Substitution/OAT

The cost and impact of distributing naloxone to people who are prescribed opioids to prevent opioid-related deaths: findings from a modelling study

Although most opioid-related mortality in Australia involves prescription opioids, most research to understand the impact of naloxone supply on opioid-related mortality has focused upon people who inj
Original research | 2021
Mortality, Harm reduction, Policy/Regulatory, About prescribers

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