Original research
by
Oviedo-Joekes, Eugenia et al
Release Date
2016
Geography
Canada
Language of Resource
English
Full Text Available
Yes
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
To test if injectable hydromorphone hydrochloride is noninferior to injectable diacetylmorphine in reducing illicit heroin use for chronic injection opioid users after 6 months of intervention.
Findings/Key points
Conclusions and Relevance This study provides evidence to suggest noninferiority of injectable hydromorphone relative to diacetylmorphine for long-term opioid dependence. In jurisdictions where diacetylmorphine is currently not available or for patients in whom it is contraindicated or unsuccessful, hydromorphone could be offered as an alternative.
Design/methods
n=202, double blind. Participants were randomly assigned to receive injectable diacetylmorphine or hydromorphone (up to 3 times daily) for 6 months under supervision.
Keywords
Evidence base
Policy/Regulatory
Safer supply
Advocacy
About prescribers
Outcomes
Illegal drugs
Substitution/OAT
