Original research
par
Oviedo-Joekes, Eugenia et al
Date de publication
2016
Géographie
Canada
Langue de la ressource
English
Texte disponible en version intégrale
Oui
Open Access / OK to Reproduce
Non
Évalué par des pairs
Yes
L’objectif
To test if injectable hydromorphone hydrochloride is noninferior to injectable diacetylmorphine in reducing illicit heroin use for chronic injection opioid users after 6 months of intervention.
Constatations/points à retenir
Conclusions and Relevance This study provides evidence to suggest noninferiority of injectable hydromorphone relative to diacetylmorphine for long-term opioid dependence. In jurisdictions where diacetylmorphine is currently not available or for patients in whom it is contraindicated or unsuccessful, hydromorphone could be offered as an alternative.
La conception ou méthodologie de recherche
n=202, double blind. Participants were randomly assigned to receive injectable diacetylmorphine or hydromorphone (up to 3 times daily) for 6 months under supervision.
Mots clés
Evidence base
Policy/Regulatory
Safer supply
Advocacy
About prescribers
Outcomes
Illegal drugs
Substitution/OAT
