Original research
by
Oviedo-Joekes, Eugenia et al
Release Date
2009
Geography
Canada
Language of Resource
English
Full Text Available
Yes
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
We compared injectable diacetylmorphine with oral methadone maintenance therapy in patients with opioid dependence that was refractory to treatment
Findings/Key points
Injectable diacetylmorphine was more effective than oral methadone. Because of a risk of overdoses and seizures, diacetylmorphine maintenance therapy should be delivered in settings where prompt medical intervention is available.
Design/methods
n=226 randomized to methadone or diacetylmorphine
Keywords
Evidence base
Policy/Regulatory
Safer supply
About prescribers
Outcomes
Illegal drugs
Substitution/OAT
