Original research
by
Johnson, Bankole A. et al
Release Date
2013
Geography
USA
Language of Resource
English
Full Text Available
Yes
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
To determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.
Findings/Key points
Topiramate is more efficacious than placebo at increasing the mean weekly proportion of cocaine nonuse days and associated measures of clinical improvement among cocaine-dependent individuals.
Design/methods
Double-blind, randomized, placebo-controlled, 12-week trial of 142 cocaine-dependent adults in clinical research facilities at the University of Virginia between November 22, 2005, and July 25, 2011.
Keywords
Stimulants
Substitution/OAT
