Lit review
by
Klimas, Jan et al
Release Date
2019
Geography
International
Language of Resource
English
Full Text Available
Yes
Open Access / OK to Reproduce
Yes
Peer Reviewed
Yes
Objective
To assess the efficacy of slow release oral morphine (SROM) as a treatment for opioid use disorder
Findings/Key points
Meta-analysis of existing randomised trials suggests SROM may be generally equal to methadone in retaining patients in treatment and reducing heroin use while potentially resulting in less craving. The methodological quality of the included RCTs was low-to-moderate.
Design/methods
We included RCTs (n=471) of all durations, assessing the effect of SROM on measures of treatment retention, heroin use and craving in adults who met the diagnostic criteria for OUD
Keywords
Evidence base
Safer supply
About prescribers
Outcomes
Illegal drugs
Substitution/OAT
