Lit review
par
Klimas, Jan et al
Date de publication
2019
Géographie
International
Langue de la ressource
English
Texte disponible en version intégrale
Oui
Open Access / OK to Reproduce
Oui
Évalué par des pairs
Yes
L’objectif
To assess the efficacy of slow release oral morphine (SROM) as a treatment for opioid use disorder
Constatations/points à retenir
Meta-analysis of existing randomised trials suggests SROM may be generally equal to methadone in retaining patients in treatment and reducing heroin use while potentially resulting in less craving. The methodological quality of the included RCTs was low-to-moderate.
La conception ou méthodologie de recherche
We included RCTs (n=471) of all durations, assessing the effect of SROM on measures of treatment retention, heroin use and craving in adults who met the diagnostic criteria for OUD
Mots clés
Evidence base
Safer supply
About prescribers
Outcomes
Illegal drugs
Substitution/OAT
