Original research
by
Nikoo, Mohammadali et al
Release Date
2022
Geography
Iran
Language of Resource
English
Full Text Available
No
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
To test if opium tincture (OT) was non-inferior to methadone in retaining participants in opioid agonist treatment (OAT).
Findings/Key points
While this study could not conclude the non-inferiority of opium tincture (OT) to methadone for retaining patients in opioid agonist treatment, OT retained 60% of participants to end of follow-up (85 days) and was superior to methadone in reducing self-reported opioid use outside treatment.
Design/methods
A Phase III, multi-centre, parallel-group, non-inferiority, double-blind randomized controlled trial with an allocation ratio of 1:1.
Keywords
Safer supply
Evidence base
Substitution/OAT
