Original research
par
Nikoo, Mohammadali et al
Date de publication
2022
Géographie
Iran
Langue de la ressource
English
Texte disponible en version intégrale
Non
Open Access / OK to Reproduce
Non
Évalué par des pairs
Yes
L’objectif
To test if opium tincture (OT) was non-inferior to methadone in retaining participants in opioid agonist treatment (OAT).
Constatations/points à retenir
While this study could not conclude the non-inferiority of opium tincture (OT) to methadone for retaining patients in opioid agonist treatment, OT retained 60% of participants to end of follow-up (85 days) and was superior to methadone in reducing self-reported opioid use outside treatment.
La conception ou méthodologie de recherche
A Phase III, multi-centre, parallel-group, non-inferiority, double-blind randomized controlled trial with an allocation ratio of 1:1.
Mots clés
Safer supply
Evidence base
Substitution/OAT
