Release Date
Geography
Language of Resource
Full Text Available
Open Access / OK to Reproduce
Peer Reviewed
Objective
This study leveraged new Cannabis use disorder (CanUD) genomics data to undertake genetically-informed analyses with unprecedented power, to investigate the genetic architecture and causal relationships between CanUD and lifetime cannabis use with risk for developing substance use disorders (SUDs) and substance use traits.
Findings/Key points
GenomicSEM confirmed that CanUD and cannabis use load onto different genetic factors and therefore, they differ in their their relationships with SUDs and substance use traits. This study concludes that CanUD and cannabis use can increase the risk of developing other SUDs (alcohol, opioids, and nicotine).
Design/methods
Analyses included calculating local and global genetic correlations, genomic structural equation modeling (genomicSEM), and Mendelian Randomization (MR).
