Date de publication
Géographie
Langue de la ressource
Texte disponible en version intégrale
Open Access / OK to Reproduce
Évalué par des pairs
L’objectif
This study leveraged new Cannabis use disorder (CanUD) genomics data to undertake genetically-informed analyses with unprecedented power, to investigate the genetic architecture and causal relationships between CanUD and lifetime cannabis use with risk for developing substance use disorders (SUDs) and substance use traits.
Constatations/points à retenir
GenomicSEM confirmed that CanUD and cannabis use load onto different genetic factors and therefore, they differ in their their relationships with SUDs and substance use traits. This study concludes that CanUD and cannabis use can increase the risk of developing other SUDs (alcohol, opioids, and nicotine).
La conception ou méthodologie de recherche
Analyses included calculating local and global genetic correlations, genomic structural equation modeling (genomicSEM), and Mendelian Randomization (MR).
