Efficacy and safety of tramadol in the treatment of opioid withdrawal: A meta-analysis of randomized controlled trials

Original research
by
Padhan, Milan et al

Release Date

2023

Geography

International

Language of Resource

English

Full Text Available

No

Open Access / OK to Reproduce

No

Peer Reviewed

Yes

Objective

The present meta-analysis was conducted to evaluate the efficacy and safety of tramadol in the treatment of opioid withdrawal.

Findings/Key points

Authors conclude that the efficacy of tramadol in reducing opioid withdrawal symptoms is not significantly different from comparators with low certainty of evidence against placebo, moderate against methadone, whereas with high certainty of evidence against buprenorphine and clonidine.

Design/methods

Data from eight relevant clinical trials

Keywords

Withdrawal
Clinical guidance