Original research
by
Krebs, Emanuel et al
Release Date
2021
Geography
Canada
Language of Resource
English
Full Text Available
No
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
The province of British Columbia, Canada, changed the existing oral anhydrous methadone solution to a 10-times more concentrated pre-mixed solution, Methadose®, on February 1, 2014. We aimed to assess the immediate effects of the methadone reformulation on missed doses, days off methadone, changes in medication dosing and dispensations of opioids for pain, and hospitalizations and mortality among all people receiving treatment at or near the time of the change
Findings/Key points
The regulatory change resulted in increases in treatment discontinuation, more instances of methadone dose increases, and was associated with increased prescriptions of other opioid analgesics.
Design/methods
Population-based retrospective cohort study
Keywords
Policy/Regulatory
About PWUD
Outcomes
Substitution/OAT
