Duration of use and outcomes among people with opioid use disorder initiating methadone and buprenorphine in Ontario: A population-based propensity-score matched cohort study

Original research
by
Gomes, Tara et al

Release Date

2022

Geography

Canada

Language of Resource

English

Full Text Available

No

Open Access / OK to Reproduce

No

Peer Reviewed

Yes

Objective

To characterize comparative risks and benefits of methadone versus buprenorphine/naloxone in a contemporary cohort where the unregulated drug supply is dominated by fentanyl.

Findings/Key points

Although treatment retention is higher among methadone recipients, overdose risk is also elevated compared to buprenorphine recipients. Overdose rates in the period following OAT discontinuation were higher than those observed while on treatment, but did not differ significantly by OAT type.

Design/methods

Cohort study

doi.org

Keywords

Overdose
Substitution/OAT
About PWUD
Outcomes