Original research
by
Skulberg, Arne Kristian et al
Release Date
2022
Geography
Norway
Language of Resource
English
Full Text Available
Yes
Open Access / OK to Reproduce
Yes
Peer Reviewed
Yes
Objective
To measure and evaluate clinical response to nasal naloxone in opioid overdoses in the pre-hospital environment.
Findings/Key points
Intranasal naloxone (1.4 mg/0.1 mL) was less efficient than 0.8 mg intramuscular naloxone for return to spontaneous breathing within 10 minutes in overdose patients in the pre-hospital environment when compared head-to-head. Intranasal naloxone at 1.4 mg/0.1 mL restored breathing in 80% of participants after one dose and had few mild adverse reactions.
Design/methods
Randomised, controlled, double-dummy, blinded, non-inferiority trial, and conducted at two centres. A commercially available 1.4 mg/0.1 mL intranasal naloxone was compared with 0.8 mg/2 mL naloxone administered intramuscularly.
Keywords
Overdose
Hospitals
About PWUD
Outcomes
