Original research
par
Skulberg, Arne Kristian et al
Date de publication
2022
Géographie
Norway
Langue de la ressource
English
Texte disponible en version intégrale
Oui
Open Access / OK to Reproduce
Oui
Évalué par des pairs
Yes
L’objectif
To measure and evaluate clinical response to nasal naloxone in opioid overdoses in the pre-hospital environment.
Constatations/points à retenir
Intranasal naloxone (1.4 mg/0.1 mL) was less efficient than 0.8 mg intramuscular naloxone for return to spontaneous breathing within 10 minutes in overdose patients in the pre-hospital environment when compared head-to-head. Intranasal naloxone at 1.4 mg/0.1 mL restored breathing in 80% of participants after one dose and had few mild adverse reactions.
La conception ou méthodologie de recherche
Randomised, controlled, double-dummy, blinded, non-inferiority trial, and conducted at two centres. A commercially available 1.4 mg/0.1 mL intranasal naloxone was compared with 0.8 mg/2 mL naloxone administered intramuscularly.
Mots clés
Overdose
Hospitals
About PWUD
Outcomes
