Original research
by
Larochelle, Marc R. et al
Release Date
2022
Geography
USA
Language of Resource
English
Full Text Available
Yes
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
To identify the association of opioid tapering or abrupt discontinuation with opioid overdose and suicide events among patients receiving stable long-term opioid therapy without evidence of opioid misuse.
Findings/Key points
This study identified a small absolute increase in risk of harms associated with opioid tapering compared with a stable opioid dosage. These results do not suggest that policies of mandatory dosage tapering for individuals receiving a stable long-term opioid dosage without evidence of opioid misuse will reduce short-term harm via suicide and overdose.
Design/methods
Trial emulation approach using a large US claims data set of individuals with commercial insurance or Medicare
Keywords
Substitution/OAT
Transitions in care/treatment
