Original research
by
Maust, Donovan T. et al
Release Date
2023
Geography
USA
Language of Resource
English
Full Text Available
Yes
Open Access / OK to Reproduce
Yes
Peer Reviewed
Yes
Objective
To identify the association of benzodiazepine discontinuation with mortality and other adverse events among patients prescribed stable long-term benzodiazepine therapy, stratified by baseline opioid exposure.
Findings/Key points
Discontinuation was associated with small absolute increases in mortality and other potential harms, including nonfatal overdose, suicide attempt, suicidal ideation, and emergency department visits.
Design/methods
This comparative effectiveness study with a trial emulation approach included data from a US commercial insurance database between January 1, 2013, and December 31, 2017. Eligible participants (n=353,576) were adults with stable long-term benzodiazepine prescription treatment.
Keywords
Mortality
Outcomes
Transitions in care/treatment
