Original research
par
Maust, Donovan T. et al
Date de publication
2023
Géographie
USA
Langue de la ressource
English
Texte disponible en version intégrale
Oui
Open Access / OK to Reproduce
Oui
Évalué par des pairs
Yes
L’objectif
To identify the association of benzodiazepine discontinuation with mortality and other adverse events among patients prescribed stable long-term benzodiazepine therapy, stratified by baseline opioid exposure.
Constatations/points à retenir
Discontinuation was associated with small absolute increases in mortality and other potential harms, including nonfatal overdose, suicide attempt, suicidal ideation, and emergency department visits.
La conception ou méthodologie de recherche
This comparative effectiveness study with a trial emulation approach included data from a US commercial insurance database between January 1, 2013, and December 31, 2017. Eligible participants (n=353,576) were adults with stable long-term benzodiazepine prescription treatment.
Mots clés
Mortality
Outcomes
Transitions in care/treatment
