Original research
by
Bakouni, Hamzah et al
Release Date
2023
Geography
Canada
Language of Resource
English
Full Text Available
No
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
We aimed to assess the effect of methadone on non-opioid substance use compared to buprenorphine/naloxone (BUP/NX), to explore whether non-opioid substance use is associated with opioid use and retention in treatment, and to test non-opioid use as a moderator of associations between methadone with retention in opioid agonist treatment (OAT) and opioid use compared to BUP/NX.
Findings/Key points
Methadone did not show a significant effect on overall non-opioid substance use in POUD compared to BUP/NX treatment but was associated with lower odds of benzodiazepine and THC use in particular. Non-opioid substance use did not predict OAT outcomes.
Design/methods
Secondary analysis of data from the OPTIMA trial
Keywords
Substitution/OAT
