Real-world study of multiple naloxone administration for opioid overdose reversal among bystanders

Original research
by
Abdelal, Randa et al

Release Date

2022

Geography

USA

Language of Resource

English

Full Text Available

Yes

Open Access / OK to Reproduce

Yes

Peer Reviewed

Yes

Objective

Due to the high potency of illicitly manufactured fentanyl (IMF), multiple naloxone administrations (MNA) may be needed per overdose event. It is essential to determine the patterns of naloxone use, including MNA, and preferences among bystanders who have used naloxone for opioid overdose reversal.

Findings/Key points

MNA occurred in most overdose events, often involving more sprays than are provided in one Narcan® nasal spray box, and participants predominantly expressed having a stronger preference for and confidence in an 8 mg compared to a 4 mg nasal spray.

Design/methods

Cross-sectional web-based survey (n=125) plus an open-ended voice survey (n=35)

Keywords

Overdose
Harm reduction