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Full Text Available
Open Access / OK to Reproduce
Peer Reviewed
Objective
To identify individual and initial prescription-related factors associated with an increased risk for opioid-related misuse, poisoning and dependence (MPD) in patients with non-cancer pain.
Findings/Key points
958 019 patients initiated opioid prescription from 2012 to 2018, of which 0.13% experienced misuse, poisoning, or dependence. Initiation with non-tramadol opioids, longer prescription duration, higher starting dose (>120 MME per day), male sex, younger age, lack of economic resources, and registered misuse of alcohol, were all associated with higher risk of misuse, poisoning, or dependence.
Design/methods
Cohort study linking several databases covering 5 million inhabitants of the region of Valencia, Spain, including all adults initiating prescription opioids in the period 2012–2018. To ascertain the association between the characteristics of the initial prescription choice and the risk of opioid MPD, we used shared frailty Cox regression models.
