How do naloxone-based interventions work to reduce overdose deaths: a realist review

Lit review
by
Miller, Nicole M. et al

Release Date

2022

Geography

International

Language of Resource

English

Full Text Available

Yes

Open Access / OK to Reproduce

Yes

Peer Reviewed

Yes

Objective

This realist systematic review aims to identify a theory of how naloxone works based on the contexts and mechanisms that contribute to the success of the intervention for improved outcomes.

Findings/Key points

Peer-to-peer models of training are helpful as it reinforces social identity and successful skills transfer between bystanders. Health systems may want to assess the prevalence of, and take steps to reduce opioid-related stigma with key stakeholders in contexts using a low threshold training approach to build an environment  to support positive naloxone outcomes.

Keywords

Overdose
Harm reduction
About PWUD
Stigma
Peer/PWLLE program involvement