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Objective
We determined the association between prescribed opioid receipt with incident cardiovascular disease (CVD).
Findings/Key points
Prevalence of hypertension, diabetes, current smoking, alcohol and cocaine use disorder, and depression was higher in patients receiving opioids versus those not but were well-balanced by matching weights. Unadjusted CVD incidence rates per 1,000-person-years were higher among those receiving opioids versus those not: 17.4 versus 14.7. In adjusted analyses, those receiving opioids versus those not had an increased hazard of incident CVD.
Design/methods
Data from the Veterans Aging Cohort Study, a national prospective cohort of Veterans with/without Human Immunodeficiency Virus (HIV) receiving Veterans Health Administration care.