Resources

Welcome to our searchable resource and literature collection on safer supply and related topics.

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Evidence synthesis – Patterns and motivations of polysubstance use: a rapid review of the qualitative evidence

The objective of this review was to synthesize current knowledge of the reasons for combining substances in a single defined episode of drug use.

Lit review | 2022
About PWUD, Illegal drugs, Stimulants

Polysubstance use poisoning deaths in Canada: an analysis of trends from 2014 to 2017 using mortality dataa

Current evidence suggests that the non-medical use of synthetic opioids, stimulants and patterns of polysubstance use are major factors contributing to the increase in drug poisoning deaths in Cana

Original research | 2022
Mortality, About PWUD, Stimulants

Association Between Law Enforcement Seizures of Illicit Drugs and Drug Overdose Deaths Involving Cocaine and Methamphetamine, Ohio, 2014–2019

Law enforcement drug seizure data present a unique opportunity to examine the association between illicit-stimulant-involved overdose deaths (ISODs) and the illicit drug supply.
Original research | 2022
Overdose, Mortality, About PWUD, Legal system/law enforcement, Illegal drugs, Stimulants

Trends in comorbid opioid and stimulant use disorders among Veterans receiving care from the Veterans Health Administration, 2005-2019

There is evidence of change in recent substance type associated with morbidity and mortality.
Original research | 2022
Overdose, Mortality, Harm reduction, About PWUD, Illegal drugs, Stimulants

Sustained-release dexamfetamine in the treatment of chronic cocaine-dependent patients on heroin-assisted treatment: a randomised, double-blind, placebo-controlled trial

Heroin-assisted treatment is eff ective for methadone treatment-refractory heroin-dependent patients, but continued comorbid cocaine dependence remains problematic.
Original research | 2016
Safer supply, About PWUD, Outcomes, Illegal drugs, Stimulants

Characterizing stimulant overdose: A qualitative study on perceptions and experiences of “overamping”

This study explores how PWUS understand, experience, and respond to overamping.
Original research | 2022
Overdose, About PWUD, Illegal drugs, Stimulants

Connecting: A Guide to Using Harm Reduction Supplies as Engagement Tools

Connecting - A Guide to Using Harm Reduction Supplies as Engagement Tools was developed to support frontline workers in their day to day work.

Guide or handbook | 2020
Harm reduction, Wrap-around services, About prescribers, Social services, Illegal drugs, Stimulants, Injecting drugs

Latent patterns of polysubstance use among people who use opioids: A systematic review

Person-centered analytical approaches (e.g., latent class analysis) provide a holistic understanding of individuals’ substance use patterns and help understand PSU heterogeneities among PWUO and their
Lit review | 2022
About PWUD, Housing, Legal system/law enforcement, Illegal drugs, Stimulants, Mental health

Topiramate for the Treatment of Cocaine Addiction: A Randomized Clinical Trial

To determine the efficacy of topiramate vs placebo as a treatment for cocaine dependence.

Original research | 2013
Stimulants, Substitution/OAT

Treatment Approaches for Users of Methamphetamine: A Practical Guide for Frontline Workers

Alcohol and other drug (AOD) workers from a variety of service settings are now frequently required to respond to methamphetamine users who are experiencing the harmful effects of methamphetamine, goi
Guide or handbook | 2008
Clinical guidance, Harm reduction, About prescribers, Social services, Illegal drugs, Stimulants, Transitions in care/treatment

“It’s called overamping”: experiences of overdose among people who use methamphetamine

We explore qualitative narratives of methamphetamine overdose and strategies used by people who use drugs to reduce the undesirable effects associated with methamphetamine use.
Original research | 2022
Overdose, Harm reduction, About PWUD, Illegal drugs, Stimulants

Patterns of Medication and Healthcare Use among People who Died of an Opioid-Related Toxicity during the COVID-19 Pandemic in Ontario

Report | 2022
Overdose, Mortality, Evidence base, About PWUD, Outcomes, Housing, Illegal drugs, Stimulants, Substitution/OAT, Mental health

Promising outcomes from a cognitive behavioral therapy text-messaging intervention targeting drug use, antiretroviral therapy adherence, and HIV risk behaviors among adults living with HIV and substance use disorders

We developed and evaluated a 12-week, CBT-based text-messaging intervention (TXT-CBT) targeting drug use and adherence to antiretroviral therapy (ART) for adults with HIV and comorbid opioid and stimu
Original research | 2021
About PWUD, Outcomes, Illegal drugs, Stimulants, Digital health

Stimulant safe supply: a potential opportunity to respond to the overdose epidemic

Current treatments for stimulant use disorder have limited effectiveness, and even less applicability to the lived realities of marginalized stimulant users.
Commentary | 2020
Policy/Regulatory, Safer supply, Equity, Advocacy, Illegal drugs, Stimulants

Toxicology and prescribed medication histories among people experiencing fatal illicit drug overdose in British Columbia, Canada

Our objective was to assess prescription history in the context of postmortem toxicology among people who had a fatal illicit drug overdose in BC.
Original research | 2020
Overdose, Mortality, Evidence base, Safer supply, Outcomes, Illegal drugs, Stimulants

A Treatment Algorithm for Attention Deficit Hyperactivity Disorder in Cocaine-Dependent Adults: A One-Year Private Practice Study with Long-Acting Stimulants, Fluoxetine, and Bupropion

We report evidence that study subjects probably medicated their ADHD symptoms with cocaine and describe a 1‐year treatment algorithm featuring long‐acting stimulants that was effective in the manageme
Original research | 1999
About prescribers, Outcomes, Illegal drugs, Stimulants

Crystal Meth, Opiates, Overdose and Housing in Kingston, Ontario: 2021 Rapid Assessment and Reponse

The people who frequent the Integrated Care Hub (ICH) – its stakeholders – know best what they are experiencing and what they need.

Report | 2021
Overdose, Evidence base, Harm reduction, Policy/Regulatory, Wrap-around services, Safer supply, Decriminalization/legalization, Equity, About PWUD, Social services, Barriers and enablers, Poverty, Housing, Crime, Legal system/law enforcement, Illegal drugs, Chronic pain, Indigenous, Small/medium cities, Stimulants, Sex/Gender , Stigma, Mental health

Safer Crack Smoking

Handout | 2020
Harm reduction, Illegal drugs, Stimulants

Safer Crystal Meth Smoking

Handout | 2020
Harm reduction, Illegal drugs, Stimulants

Validation of the tobacco, alcohol, prescription medication, and other substance use (TAPS) tool with the WHO alcohol, smoking, and substance Involvement screening test

The goal of this study was to validate the performance of the Tobacco, Alcohol, Prescription medication, and other Substance use (TAPS) tool in community pharmacy settings compared to a reference-stan
Original research | 2021
About pharmacists, Illegal drugs, Stimulants

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