Examining the association between fentanyl use and perceived adequacy of methadone dose: A retrospective cohort study

Original research
par
Young, Samantha et al

Date de publication

2025

Géographie

Canada

Langue de la ressource

English

Texte disponible en version intégrale

Non

Open Access / OK to Reproduce

Non

Évalué par des pairs

Yes

L’objectif

People exposed to fentanyl may report that the dose of methadone in the commonly accepted therapeutic range feels too low. This paper examines self-reported methadone dose adequacy.

Constatations/points à retenir

The analysis demonstrates that exposure to non-fentanyl opioids while on methadone was not associated with feeling the dose was too low compared with individuals exposed to fentanyl. Our findings support adequate titration of methadone for individuals with continued exposure to unregulated opioids including fentanyl.

La conception ou méthodologie de recherche

A retrospective cohort study of individuals prescribed methadone at a dose of at least 60 mg daily using data from three community-recruited prospective cohort studies of people who use drugs in Vancouver, Canada from December 2016 through March 2020. 

Mots clés

Advocacy
About PWUD
Illegal drugs
Opioids
Peer/PWLLE program involvement
Substitution/OAT
Withdrawal