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This rapid review on overdose prevention centres (OPCs) aims to collate and summarise existing evidence. It describes the impact of OPCs on individuals who use drugs, communities, and public health. This is to support decision making and understanding of service provision for health departments, potential providers, researchers, and elected officials (1). This document also covers some practical matters of running a service including day-to-day matters, costs, and any cost savings from their operation. We conclude with information on evaluation; services should be robustly evaluated.