Original research
par
Powell, David, Evan D. Peet & Rosalie Liccardo Pacula
Date de publication
2023
Géographie
USA
Langue de la ressource
English
Texte disponible en version intégrale
Non
Open Access / OK to Reproduce
Non
Évalué par des pairs
Yes
L’objectif
We examine if the shift to the illicit market after the reformulation of OxyContin in the U.S. in 2010 also led to a rise in polysubstance overdose deaths involving non-opioid prescription drugs, including gabapentinoids and “Z-drugs” and, separately, benzodiazepines.
Constatations/points à retenir
Exposure to reformulation predicted growth in overdose deaths involving gabapentinoids and Z-drugs. There is less evidence that it predicted growth in overdose deaths involving benzodiazepines. However, for all substances, there is strong evidence that pre-reformulation OxyContin misuse rates predicted post-reformulation growth in overdose deaths concurrently involving synthetic opioids.
Mots clés
Overdose
Mortality
Policy/Regulatory
Outcomes
