Original research
par
Bozinoff, Nikki et al
Date de publication
2022
Géographie
Canada
Langue de la ressource
English
Texte disponible en version intégrale
Oui
Open Access / OK to Reproduce
Oui
Évalué par des pairs
Yes
L’objectif
To understand what prescribing characteristics are associated with opioid overdose following buprenorphine taper.
Constatations/points à retenir
In this retrospective cohort study, buprenorphine tapers undertaken after at least 1 year of therapy, a slower rate of taper, and a lower percentage of days during which the dose was decreasing were associated with a significantly lower risk of opioid overdose, regardless of taper duration. These findings underscore the importance of a carefully planned taper and could contribute to reduction in opioid-related overdose death.
La conception ou méthodologie de recherche
Population-based retrospective cohort study using linked administrative health data
Mots clés
Substitution/OAT
Overdose
Transitions in care/treatment
About PWUD
Clinical guidance
