The evolving consequences of Oxycontin reformulation on drug overdoses

Original research
par
Powell, David, & Rosalie Liccardo Pacula

Date de publication

2021

Géographie

USA

Langue de la ressource

English

Texte disponible en version intégrale

Oui

Open Access / OK to Reproduce

Non

Évalué par des pairs

Yes

L’objectif

Recent evidence suggests that the short-term transition of the opioid crisis from prescription opioids to heroin can be attributed to the reformulation of OxyContin, which substantially reduced access to abusable prescription opioids.

Constatations/points à retenir

In this paper, we find that over a longer time horizon, reformulation stimulated illicit drug markets to grow and evolve. More exposed areas experienced disproportionate increases in fatal overdoses involving synthetic opioids (fentanyl) and nonopioid substances like cocaine, suggesting that these new epidemics are related to the same factors driving the rise in heroin deaths. Instead of just short-term substitution from prescription opioid to heroin overdoses, the transition to illicit markets spurred by reformulation led to growth in the overall overdose rate to unprecedented levels.

La conception ou méthodologie de recherche

We compare overdose trajectories in areas more exposed to reformulation, defined as states with higher rates of nonmedical OxyContin use before reformulation, to less exposed areas.

Mots clés

Overdose
Illegal drugs
Outcomes