Amphetamines Modulate Fentanyl-Depressed Respiration in a Bidirectional Manner

Original research
par
Elder, Harrison J. et al

Date de publication

2022

Géographie

USA

Langue de la ressource

English

Texte disponible en version intégrale

Non

Open Access / OK to Reproduce

Non

Évalué par des pairs

Yes

L’objectif

Deaths involving opioids typically result from lethal respiratory depression, and it is currently unknown how co-use of psychostimulants with opioids affects respiratory toxicity.

Constatations/points à retenir

These results indicate that co-use of amphetamines with fentanyl may worsen respiratory depression, but conversely, monoaminergic components of the amphetamines may possibly be exploited to mitigate fentanyl overdose.

La conception ou méthodologie de recherche

Mouse study

Mots clés

Stimulants
Overdose