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This practice update is composed of two parts. The first provides updates on the provision of opioid agonist treatment (OAT) in line with planned updates to the forthcoming provincial OUD Guideline. These updates are based on research evidence published since the 2017 OUD Guideline was published, as well as clinical experience in BC. The second part provides an overview of clinical experience and preliminary data from a year of Risk Mitigation prescribing, and introduces practice options to reduce individuals’ reliance on the illicit opioid supply and related risks, including illicit drug poisoning, outside of the context of risk of COVID-19.