Original research
par
Marwah, Radhika et al
Date de publication
2020
Géographie
Canada
Langue de la ressource
English
Texte disponible en version intégrale
Oui
Open Access / OK to Reproduce
Non
Évalué par des pairs
No
L’objectif
To raise awareness of alternative techniques that can facilitate buprenorphine-naloxone treatment for opioid use disorder.
Constatations/points à retenir
A drawback to traditional initiation of buprenorphine-naloxone is that before induction patients must have abstained from opioids for a minimum of 12 to 36 hours to prevent precipitated withdrawal, which occurs owing to displacement of full opioid agonists from the µ-receptor. This abstention presents a considerable barrier to treatment initiation.1,3 A novel off-label approach known as microdosing or the Bernese method3 might serve as a valuable tool to ease buprenorphine-naloxone induction for both patients and prescribers by circumventing the withdrawal impediment.
Mots clés
Clinical guidance
Harm reduction
About prescribers
Substitution/OAT
